allergicNo dedicated ICD-10 code

Alpha-gal Syndrome

IgE-mediated allergy to galactose-alpha-1,3-galactose triggered by Lone Star tick bites, causing delayed allergic reactions to mammalian meat.

US Prevalence

450.0K

estimated affected individuals

Annual New Cases

50.0K

new diagnoses per year

Diagnostic Delay

7 years

average time to diagnosis

Annual Cost / Patient

$2,100

national burden: >$970M modeled

Key Facts

Critical data points clinicians and policymakers should know

Only 110,000 identified — 75% diagnostic undercount
NOT nationally notifiable disease
No dedicated ICD-10 code
Primary vector: Lone Star tick (Amblyomma americanum)
Inverse correlation with fire ant distribution (ecological paradox)

Related Symptoms

5 documented symptoms across 4 body systems

immunological

Delayed Reaction to Mammalian Meat
Anaphylaxis

cardiovascular

Heart Palpitations

dermatological

Hives / Urticaria

gastrointestinal

GI Distress (Nausea, Cramping)

Symptom Overlap with Other Conditions

Conditions that share symptoms with Alpha-gal Syndrome, ranked by number of shared symptoms. High overlap can contribute to misdiagnosis and diagnostic delay.

Long COVID2 shared

40% of Alpha-gal Syndrome symptoms

Heart PalpitationsGI Distress (Nausea, Cramping)

ME/CFS1 shared

20% of Alpha-gal Syndrome symptoms

GI Distress (Nausea, Cramping)

POTS1 shared

20% of Alpha-gal Syndrome symptoms

Heart Palpitations

Economic Impact

Published economic burden data for Alpha-gal Syndrome

Modeled Burden

>$970M

JACI-IP 2026 (2026)

Diagnostic Undercount

75%

CDC MMWR 2023 (2023)

Severity at a Glance

Comparative metrics placing Alpha-gal Syndrome in context

Long COVID18.0M

Fibromyalgia10.0M

ME/CFS3.3M

POTS3.0M

Lyme Disease2.0M

Alpha-gal Syndrome (this condition)450.0K

Take Action

Use InvisibleSignal tools to screen, find care, or understand costs

Take Symptom ScreenerAI-powered pre-screening tool Find ProvidersSpecialists near you Calculate CostsPer-patient cost estimator

Data sourced from CDC, Census Bureau (HPS), CMS, NIH, AHRQ, and peer-reviewed literature. Last updated August 2026.

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allergicNo dedicated ICD-10 code

Alpha-gal Syndrome

IgE-mediated allergy to galactose-alpha-1,3-galactose triggered by Lone Star tick bites, causing delayed allergic reactions to mammalian meat.

US Prevalence

450.0K

estimated affected individuals

Annual New Cases

50.0K

new diagnoses per year

Diagnostic Delay

7 years

average time to diagnosis

Annual Cost / Patient

$2,100

national burden: >$970M modeled

Key Facts

Critical data points clinicians and policymakers should know

Only 110,000 identified — 75% diagnostic undercount
NOT nationally notifiable disease
No dedicated ICD-10 code
Primary vector: Lone Star tick (Amblyomma americanum)
Inverse correlation with fire ant distribution (ecological paradox)

Related Symptoms

5 documented symptoms across 4 body systems

immunological

Delayed Reaction to Mammalian Meat
Anaphylaxis

cardiovascular

Heart Palpitations

dermatological

Hives / Urticaria

gastrointestinal

GI Distress (Nausea, Cramping)

Symptom Overlap with Other Conditions

Conditions that share symptoms with Alpha-gal Syndrome, ranked by number of shared symptoms. High overlap can contribute to misdiagnosis and diagnostic delay.

Long COVID2 shared

40% of Alpha-gal Syndrome symptoms

Heart PalpitationsGI Distress (Nausea, Cramping)

ME/CFS1 shared

20% of Alpha-gal Syndrome symptoms

GI Distress (Nausea, Cramping)

POTS1 shared

20% of Alpha-gal Syndrome symptoms

Heart Palpitations

Economic Impact

Published economic burden data for Alpha-gal Syndrome

Modeled Burden

>$970M

JACI-IP 2026 (2026)

Diagnostic Undercount

75%

CDC MMWR 2023 (2023)

Severity at a Glance

Comparative metrics placing Alpha-gal Syndrome in context

Long COVID18.0M

Fibromyalgia10.0M

ME/CFS3.3M

POTS3.0M

Lyme Disease2.0M

Alpha-gal Syndrome (this condition)450.0K

Take Action

Use InvisibleSignal tools to screen, find care, or understand costs

Take Symptom ScreenerAI-powered pre-screening tool Find ProvidersSpecialists near you Calculate CostsPer-patient cost estimator

Data sourced from CDC, Census Bureau (HPS), CMS, NIH, AHRQ, and peer-reviewed literature. Last updated August 2026.