tickborneICD-10: A69.20ICD-10: A69.21ICD-10: A69.22ICD-10: A69.23ICD-10: A69.29

Lyme Disease

The most prevalent arthropod-borne infectious disease in the U.S., caused by Borrelia burgdorferi transmitted by Ixodes ticks.

US Prevalence

2.0M

estimated affected individuals

Annual New Cases

476.0K

new diagnoses per year

Diagnostic Delay

4.4 years

average time to diagnosis

Annual Cost / Patient

$2,032

national burden: $712M-$1.3B/year

Key Facts

Critical data points clinicians and policymakers should know

476,000 diagnosed annually (CDC)
Two-tier testing has <50% sensitivity in early stage
10-20% develop persistent symptoms (Lyme-IACCI)
Erythema migrans rash present in ~70-80% of cases
No dedicated ICD-10 code for chronic Lyme/PTLDS

Related Symptoms

16 documented symptoms across 7 body systems

neurological

Brain Fog / Cognitive Dysfunction
Headache
Numbness / Tingling
Facial Palsy / Bell's Palsy
Memory Loss

musculoskeletal

Joint Pain / Arthralgia
Muscle Pain / Myalgia
Neck Stiffness

systemic

Persistent Fatigue
Fever / Chills

psychiatric

Anxiety
Depression

sensory

Light Sensitivity
Tinnitus

autonomic

Dizziness / Lightheadedness

dermatological

Erythema Migrans Rash

Economic Impact

Published economic burden data for Lyme Disease

Per-Patient OOP Cost

$1,252

Hook et al. 2022, CDC/EID (2022)

Per-Patient Societal Cost

$2,032

Hook et al. 2022, CDC/EID (2022)

PTLDS Annual Premium

+$3,798

Adrion et al. 2015, Johns Hopkins (2015)

National Annual Burden

$712M-$1.3B

Johns Hopkins 2015 (2015)

Rural Claims Growth

357%

FAIR Health 2007-2021 (2021)

Severity at a Glance

Comparative metrics placing Lyme Disease in context

Lyme Disease (this condition)2.0M

Take Action

Use InvisibleSignal tools to screen, find care, or understand costs

Take Symptom ScreenerAI-powered pre-screening tool Find ProvidersSpecialists near you Diagnostic JourneyTypical delays and misdiagnoses

Data sourced from CDC, Census Bureau (HPS), CMS, NIH, AHRQ, and peer-reviewed literature. Last updated August 2026.

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tickborneICD-10: A69.20ICD-10: A69.21ICD-10: A69.22ICD-10: A69.23ICD-10: A69.29

Lyme Disease

The most prevalent arthropod-borne infectious disease in the U.S., caused by Borrelia burgdorferi transmitted by Ixodes ticks.

US Prevalence

2.0M

estimated affected individuals

Annual New Cases

476.0K

new diagnoses per year

Diagnostic Delay

4.4 years

average time to diagnosis

Annual Cost / Patient

$2,032

national burden: $712M-$1.3B/year

Key Facts

Critical data points clinicians and policymakers should know

476,000 diagnosed annually (CDC)
Two-tier testing has <50% sensitivity in early stage
10-20% develop persistent symptoms (Lyme-IACCI)
Erythema migrans rash present in ~70-80% of cases
No dedicated ICD-10 code for chronic Lyme/PTLDS

Related Symptoms

16 documented symptoms across 7 body systems

neurological

Brain Fog / Cognitive Dysfunction
Headache
Numbness / Tingling
Facial Palsy / Bell's Palsy
Memory Loss

musculoskeletal

Joint Pain / Arthralgia
Muscle Pain / Myalgia
Neck Stiffness

systemic

Persistent Fatigue
Fever / Chills

psychiatric

Anxiety
Depression

sensory

Light Sensitivity
Tinnitus

autonomic

Dizziness / Lightheadedness

dermatological

Erythema Migrans Rash

Economic Impact

Published economic burden data for Lyme Disease

Per-Patient OOP Cost

$1,252

Hook et al. 2022, CDC/EID (2022)

Per-Patient Societal Cost

$2,032

Hook et al. 2022, CDC/EID (2022)

PTLDS Annual Premium

+$3,798

Adrion et al. 2015, Johns Hopkins (2015)

National Annual Burden

$712M-$1.3B

Johns Hopkins 2015 (2015)

Rural Claims Growth

357%

FAIR Health 2007-2021 (2021)

Severity at a Glance

Comparative metrics placing Lyme Disease in context

Lyme Disease (this condition)2.0M

Take Action

Use InvisibleSignal tools to screen, find care, or understand costs

Take Symptom ScreenerAI-powered pre-screening tool Find ProvidersSpecialists near you Diagnostic JourneyTypical delays and misdiagnoses

Data sourced from CDC, Census Bureau (HPS), CMS, NIH, AHRQ, and peer-reviewed literature. Last updated August 2026.