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Symptom Overlap Matrix

Interactive visualization of shared symptoms across invisible illnesses

Most Overlapping Pair

Lyme & Long COVID

100%

shared symptom presence

Conditions Tracked

invisible illness conditions

Symptoms Mapped

cross-condition symptoms

Prevalence: Common (>60%) Moderate (30-60%) Rare (10-30%) Absent (<10%)Click a row or column to highlight

Symptom-by-Condition Matrix

Symptom	Lyme	Long COVID	ME/CFS	Fibromyalgia	POTS	Alpha-gal
Fatigue
Brain fog
Joint pain
Muscle pain
Headaches
Dizziness
Heart palpitations
Sleep disturbance
GI issues
Numbness/tingling
Fever
Night sweats
Light sensitivity
Sound sensitivity
Exercise intolerance
Shortness of breath
Skin rashes
Cognitive impairment
Anxiety
Depression

Most Unique Symptom per Condition

Lyme

Fever

Long COVID

Shortness of breath

ME/CFS

Exercise intolerance

Fibromyalgia

Muscle pain

POTS

Heart palpitations

Alpha-gal

GI issues

Diagnostic Differentiators

What makes each condition clinically distinct despite extensive symptom overlap

Lyme Disease

Erythema migrans (bull's-eye) rash
Known tick bite / endemic area exposure
Response to doxycycline or other antibiotics
Positive two-tier serologic testing (ELISA + Western Blot)

Long COVID

Documented COVID-19 infection history
Symptom onset within 4-12 weeks post-infection
Pulmonary & vascular involvement common
Loss of smell/taste as distinguishing early symptom

ME/CFS

Post-exertional malaise (PEM) as hallmark criterion
Unrefreshing sleep despite duration
Symptom flare 12-72 hours after exertion
No alternative medical explanation after thorough workup

Fibromyalgia

Widespread tender points (11+ of 18 sites)
Central sensitization and allodynia
Pain amplification without tissue damage
Responds to pregabalin / duloxetine

POTS

Heart rate increase >30 bpm within 10 min of standing
Orthostatic intolerance without hypotension
Confirmed by tilt-table test
Blood pooling in lower extremities

Alpha-gal Syndrome

Delayed allergic reaction to mammalian meat (3-6 hrs)
Lone star tick bite history
Positive alpha-gal IgE antibody test
Tolerance of poultry, fish, and plant proteins

Explore Related Modules

Compare Conditions

Side-by-side condition analysis

Pattern Engine

Cross-condition analysis

Symptom Screener

Clinical pre-screening tool

Demographics

Prevalence disparities

Data Sources (8)

CDC. Lyme Disease: Clinical Manifestations. 2024.
CDC. Post-COVID Conditions: Science-Based Information. 2024.
NIH / NINDS. ME/CFS Diagnosis and Symptom Overview. 2023.
NIH / NIAMS. Fibromyalgia Prevalence and Symptom Studies. 2023.
NIH / NINDS. Postural Orthostatic Tachycardia Syndrome. 2024.
CDC. Alpha-gal Syndrome: Tick-Borne Meat Allergy. 2024.
Journal of Internal Medicine. Symptom Overlap in Post-Infectious Fatigue Syndromes. 2023.
Annals of Internal Medicine. Diagnostic Challenges in Overlapping Chronic Conditions. 2022.

Symptom Overlap Matrix

Interactive visualization of shared symptoms across invisible illnesses

Most Overlapping Pair

Lyme & Long COVID

100%

shared symptom presence

Conditions Tracked

invisible illness conditions

Symptoms Mapped

cross-condition symptoms

Prevalence: Common (>60%) Moderate (30-60%) Rare (10-30%) Absent (<10%)Click a row or column to highlight

Symptom-by-Condition Matrix

Symptom	Lyme	Long COVID	ME/CFS	Fibromyalgia	POTS	Alpha-gal
Fatigue
Brain fog
Joint pain
Muscle pain
Headaches
Dizziness
Heart palpitations
Sleep disturbance
GI issues
Numbness/tingling
Fever
Night sweats
Light sensitivity
Sound sensitivity
Exercise intolerance
Shortness of breath
Skin rashes
Cognitive impairment
Anxiety
Depression

Most Unique Symptom per Condition

Lyme

Fever

Long COVID

Shortness of breath

ME/CFS

Exercise intolerance

Fibromyalgia

Muscle pain

POTS

Heart palpitations

Alpha-gal

GI issues

Diagnostic Differentiators

What makes each condition clinically distinct despite extensive symptom overlap

Lyme Disease

Erythema migrans (bull's-eye) rash
Known tick bite / endemic area exposure
Response to doxycycline or other antibiotics
Positive two-tier serologic testing (ELISA + Western Blot)

Long COVID

Documented COVID-19 infection history
Symptom onset within 4-12 weeks post-infection
Pulmonary & vascular involvement common
Loss of smell/taste as distinguishing early symptom

ME/CFS

Post-exertional malaise (PEM) as hallmark criterion
Unrefreshing sleep despite duration
Symptom flare 12-72 hours after exertion
No alternative medical explanation after thorough workup

Fibromyalgia

Widespread tender points (11+ of 18 sites)
Central sensitization and allodynia
Pain amplification without tissue damage
Responds to pregabalin / duloxetine

POTS

Heart rate increase >30 bpm within 10 min of standing
Orthostatic intolerance without hypotension
Confirmed by tilt-table test
Blood pooling in lower extremities

Alpha-gal Syndrome

Delayed allergic reaction to mammalian meat (3-6 hrs)
Lone star tick bite history
Positive alpha-gal IgE antibody test
Tolerance of poultry, fish, and plant proteins

Explore Related Modules

Compare Conditions

Side-by-side condition analysis

Pattern Engine

Cross-condition analysis

Symptom Screener

Clinical pre-screening tool

Demographics

Prevalence disparities

Data Sources (8)

CDC. Lyme Disease: Clinical Manifestations. 2024.
CDC. Post-COVID Conditions: Science-Based Information. 2024.
NIH / NINDS. ME/CFS Diagnosis and Symptom Overview. 2023.
NIH / NIAMS. Fibromyalgia Prevalence and Symptom Studies. 2023.
NIH / NINDS. Postural Orthostatic Tachycardia Syndrome. 2024.
CDC. Alpha-gal Syndrome: Tick-Borne Meat Allergy. 2024.
Journal of Internal Medicine. Symptom Overlap in Post-Infectious Fatigue Syndromes. 2023.
Annals of Internal Medicine. Diagnostic Challenges in Overlapping Chronic Conditions. 2022.