Pattern Engine

Cross-condition symptom overlap visualization across 6 conditions and 28 symptoms

Filter by Condition

Symptom-Condition Matrix

Colored dots indicate which symptoms appear in which conditions. Symptoms appearing in 3+ conditions are highlighted.

Symptom	System	Overlap
Chronic Fatigue	systemic	5
Brain Fog / Cognitive Dysfunction	neurological	5
Joint Pain / Arthralgia	musculoskeletal	4
Headache	neurological	4
Post-Exertional Malaise	systemic	2
Heart Palpitations	cardiovascular	3
Dizziness / Lightheadedness	autonomic	3
Muscle Pain / Myalgia	musculoskeletal	4
Sleep Disruption	neurological	4
Shortness of Breath	respiratory	2
Numbness / Tingling	neurological	3
Erythema Migrans Rash	dermatological	1
Fever / Chills	systemic	2
Neck Stiffness	musculoskeletal	1
Facial Palsy / Bell's Palsy	neurological	1
Delayed Reaction to Mammalian Meat	immunological	1
Hives / Urticaria	dermatological	1
GI Distress (Nausea, Cramping)	gastrointestinal	3
Anaphylaxis	immunological	1
Loss of Smell (Anosmia)	sensory	1
Loss of Taste	sensory	1
Chest Pain	cardiovascular	2
Anxiety	psychiatric	4
Depression	psychiatric	4
Excessive Sweating	autonomic	2
Memory Loss	neurological	3
Light Sensitivity	sensory	3
Tinnitus	sensory	2

Most Overlapping Symptoms

Symptoms appearing in 3 or more conditions

5
Chronic Fatigue
Lyme DiseaseLong COVIDME/CFSPOTSFibromyalgia
5
Brain Fog / Cognitive Dysfunction
Lyme DiseaseLong COVIDME/CFSPOTSFibromyalgia
4
Joint Pain / Arthralgia
Lyme DiseaseLong COVIDME/CFSFibromyalgia
4
Headache
Lyme DiseaseLong COVIDME/CFSPOTS
4
Muscle Pain / Myalgia
Lyme DiseaseLong COVIDME/CFSFibromyalgia
4
Sleep Disruption
Long COVIDME/CFSFibromyalgiaPOTS
4
Anxiety
Long COVIDME/CFSPOTSLyme Disease
4
Depression
Long COVIDME/CFSLyme DiseaseFibromyalgia
3
Heart Palpitations
Long COVIDPOTSAlpha-gal Syndrome
3
Dizziness / Lightheadedness
Long COVIDPOTSLyme Disease
3
Numbness / Tingling
Lyme DiseaseLong COVIDFibromyalgia
3
GI Distress (Nausea, Cramping)
Alpha-gal SyndromeLong COVIDME/CFS
3
Memory Loss
Long COVIDLyme DiseaseME/CFS
3
Light Sensitivity
Lyme DiseaseME/CFSFibromyalgia

Condition Pair Overlap

Pairs of conditions sharing the most symptoms

1Lyme Disease + Long COVID
12 shared
Chronic FatigueBrain Fog / Cognitive DysfunctionJoint Pain / ArthralgiaHeadacheDizziness / LightheadednessMuscle Pain / MyalgiaNumbness / TinglingFever / ChillsAnxietyDepressionMemory LossTinnitus
2Long COVID + ME/CFS
11 shared
Chronic FatigueBrain Fog / Cognitive DysfunctionJoint Pain / ArthralgiaHeadachePost-Exertional MalaiseMuscle Pain / MyalgiaSleep DisruptionGI Distress (Nausea, Cramping)AnxietyDepressionMemory Loss
3Long COVID + POTS
10 shared
Chronic FatigueBrain Fog / Cognitive DysfunctionHeadacheHeart PalpitationsDizziness / LightheadednessSleep DisruptionShortness of BreathChest PainAnxietyExcessive Sweating
4Lyme Disease + ME/CFS
9 shared
Chronic FatigueBrain Fog / Cognitive DysfunctionJoint Pain / ArthralgiaHeadacheMuscle Pain / MyalgiaAnxietyDepressionMemory LossLight Sensitivity
5Lyme Disease + Fibromyalgia
7 shared
Chronic FatigueBrain Fog / Cognitive DysfunctionJoint Pain / ArthralgiaMuscle Pain / MyalgiaNumbness / TinglingDepressionLight Sensitivity

Total Unique Symptoms

Across 6 tracked conditions

Average Overlap

71%

Symptoms appearing in 2+ conditions

Most Distinct Condition

Alpha-gal Syndrome

Fewest shared symptoms with others

Cross-Condition Correlation

Radar profile of each condition across body systems. The shape reveals how each condition distributes its symptoms — similar shapes indicate high clinical overlap.

Diagnostic Pathway

Symptom distribution by body system for each condition. Clusters reveal which organ systems dominate each condition's presentation, helping distinguish between them.

Symptom Overlap Network

Each bubble represents a condition. Horizontal position shows how many unique symptoms it presents; vertical position shows its average overlap with all other conditions. Bubble size reflects U.S. prevalence.

Lyme Disease(2.0M)

Long COVID(18.0M)

ME/CFS(3.3M)

Alpha-gal Syndrome(450K)

POTS(3.0M)

Fibromyalgia(10.0M)

Bubble size proportional to estimated U.S. prevalence (log scale)

Condition Overlap Matrix

Pairwise symptom overlap between all 6 conditions. Each cell shows shared symptom count and overlap percentage relative to the smaller condition's symptom set. Diagonal cells show total symptom count.

Condition	Lyme Disease	Long COVID	ME/CFS	Alpha-gal Syndrome	POTS	Fibromyalgia
Lyme Disease	16symptoms	12 75%	9 75%	0 0%	5 50%	7 88%
Long COVID	12 75%	21symptoms	11 92%	2 40%	10 100%	7 88%
ME/CFS	9 75%	11 92%	12symptoms	1 20%	5 50%	7 88%
Alpha-gal Syndrome	0 0%	2 40%	1 20%	5symptoms	1 20%	0 0%
POTS	5 50%	10 100%	5 50%	1 20%	10symptoms	3 38%
Fibromyalgia	7 88%	7 88%	7 88%	0 0%	3 38%	8symptoms

High overlap (60%+)

Moderate overlap (30-59%)

Low overlap (<30%)

Key Insight

ME/CFS, Fibromyalgia, and POTS form a “triad” with >60% symptom overlap, suggesting shared pathophysiology. This makes distinguishing between them exceptionally difficult.

The overlap network reveals that these three conditions share core symptoms across neurological, autonomic, and systemic body systems -- including chronic fatigue, brain fog, sleep disruption, and anxiety. Combined with Long COVID's extensive symptom profile (which overlaps significantly with all three), clinicians face a diagnostic landscape where ruling in a specific condition requires careful attention to distinguishing features rather than presenting symptoms alone.

ME/CFSFibromyalgiaPOTS

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Symptom

System

Lyme Disease

Long COVID

ME/CFS

Alpha-gal Syndrome

POTS

Fibromyalgia

Overlap

Chronic Fatigue

systemic

Brain Fog / Cognitive Dysfunction

neurological

Joint Pain / Arthralgia

musculoskeletal

Headache

neurological

Post-Exertional Malaise

systemic

Heart Palpitations

cardiovascular

Dizziness / Lightheadedness

autonomic

Muscle Pain / Myalgia

musculoskeletal

Sleep Disruption

neurological

Shortness of Breath

respiratory

Numbness / Tingling

neurological

Erythema Migrans Rash

dermatological

Fever / Chills

systemic

Neck Stiffness

musculoskeletal

Facial Palsy / Bell's Palsy

neurological

Delayed Reaction to Mammalian Meat

immunological

Hives / Urticaria

dermatological

GI Distress (Nausea, Cramping)

gastrointestinal

Anaphylaxis

immunological

Loss of Smell (Anosmia)

sensory

Loss of Taste

sensory

Chest Pain

cardiovascular

Anxiety

psychiatric

Depression

psychiatric

Excessive Sweating

autonomic

Memory Loss

neurological

Light Sensitivity

sensory

Tinnitus

sensory

Condition

Lyme Disease

Long COVID

ME/CFS

Alpha-gal Syndrome

POTS

Fibromyalgia

Lyme Disease

16symptoms

75%

50%

88%

Long COVID

75%

21symptoms

92%

40%

100%

88%

ME/CFS

75%

92%

12symptoms

20%

50%

88%

Alpha-gal Syndrome

40%

20%

5symptoms

20%

POTS

50%

100%

50%

20%

10symptoms

38%

Fibromyalgia

88%

38%

8symptoms